Nucleic Acids in Human Glioma Treatment : Innovative Approaches and Recent Results
Joint Authors
Cerchia, Laura
Quintavalle, C.
Catuogno, S.
de Franciscis, V.
Esposito, C. L.
Condorelli, Gerolama
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gliomas are the most common primary central nervous system tumors with a dismal prognosis.
Despite recent advances in surgery, radiotherapy, and chemotherapy, current treatment regimens have a modest survival benefit.
A crucial challenge is to deliver drugs effectively to invasive glioma cells residing in a sanctuary within the central nervous system.
New therapies are essential, and oligonucleotide-based approaches, including antisense, microRNAs, small interfering RNAs, and nucleic acid aptamers, may provide a viable strategy.
Thanks to their unique characteristics (low size, good affinity for the target, no immunogenicity, chemical structures that can be easily modified to improve their in vivo applications), these molecules may represent a valid alternative to antibodies particularly to overcome challenges presented by the blood-brain barrier.
Here we will discuss recent results on the use of oligonucleotides that will hopefully provide new effective treatment for gliomas.
American Psychological Association (APA)
Catuogno, S.& Esposito, C. L.& Quintavalle, C.& Condorelli, Gerolama& de Franciscis, V.& Cerchia, Laura. 2012. Nucleic Acids in Human Glioma Treatment : Innovative Approaches and Recent Results. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494461
Modern Language Association (MLA)
Catuogno, S.…[et al.]. Nucleic Acids in Human Glioma Treatment : Innovative Approaches and Recent Results. Journal of Signal Transduction No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-494461
American Medical Association (AMA)
Catuogno, S.& Esposito, C. L.& Quintavalle, C.& Condorelli, Gerolama& de Franciscis, V.& Cerchia, Laura. Nucleic Acids in Human Glioma Treatment : Innovative Approaches and Recent Results. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494461