Latest Approved Therapies for Metastatic Melanoma : What Comes Next?
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nowadays, oncogene-directed therapy and immunotherapy represent the two most promising avenues for patients with metastatic melanoma.
The recent oncogene-directed therapeutic, vemurafenib, usually produces high level of tumor shrinkage and survival benefits in many patients with B-RAFV600E mutant melanomas, although the fast and high degrees of responses are likely short-lived.
Conversely, the newly-approved immunotherapeutic, ipilimumab, produces durable responses in patients presenting CTLA-4 T-cell surface protein.
Nevertheless, the possible synergy in combining these two therapeutic strategies primarily rely on the rational design of medical protocols (e.g., sequence and timing of agent administration; drug selectivity; compatibility of combined therapies i.e., adoptive T cell or agents, i.e., MEK inhibitor trametinib, PD-1 and PDL-1 blockers).
Improved therapeutic protocols shall overcome therapeutic limitations such as the (i) tolerability and safety (i.e., minimal toxic side-effects); (ii) progression free survival (e.g., reduced relapse disease frequency); (iii) duration response (i.e., decreased drug resistance).
Eventually, multidisciplinary approaches are still requested (e.g., genomics for personalized medicine, nanomedicine to overcome low free-drug bioavailability and targeting, systematic search of “melanoma stem cells” to enhance the prognosis and develop more valuable theranostics).
In this paper, I will mainly present and discuss the latest and promising treatments for advanced cutaneous melanomas.
American Psychological Association (APA)
Menaa, Farid. 2013. Latest Approved Therapies for Metastatic Melanoma : What Comes Next?. Journal of Skin Cancer،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494476
Modern Language Association (MLA)
Menaa, Farid. Latest Approved Therapies for Metastatic Melanoma : What Comes Next?. Journal of Skin Cancer No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-494476
American Medical Association (AMA)
Menaa, Farid. Latest Approved Therapies for Metastatic Melanoma : What Comes Next?. Journal of Skin Cancer. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-494476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494476