Age-Associated Reduction of Asymmetry in Human Central Auditory Function : A 1H-Magnetic Resonance Spectroscopy Study
Joint Authors
Wang, Cuixia
Chen, Xianming
Liang, Yonghui
Li, Jianzhong
Chen, Shiyan
Deng, Yihong
Luo, Ping
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to investigate the effects of age on hemispheric asymmetry in the auditory cortex after pure tone stimulation.
Ten young and 8 older healthy volunteers took part in this study.
Two-dimensional multivoxel 1H-magnetic resonance spectroscopy scans were performed before and after stimulation.
The ratios of N-acetylaspartate (NAA), glutamate/glutamine (Glx), and γ-amino butyric acid (GABA) to creatine (Cr) were determined and compared between the two groups.
The distribution of metabolites between the left and right auditory cortex was also determined.
Before stimulation, left and right side NAA/Cr and right side GABA/Cr were significantly lower, whereas right side Glx/Cr was significantly higher in the older group compared with the young group.
After stimulation, left and right side NAA/Cr and GABA/Cr were significantly lower, whereas left side Glx/Cr was significantly higher in the older group compared with the young group.
There was obvious asymmetry in right side Glx/Cr and left side GABA/Cr after stimulation in young group, but not in older group.
In summary, there is marked hemispheric asymmetry in auditory cortical metabolites following pure tone stimulation in young, but not older adults.
This reduced asymmetry in older adults may at least in part underlie the speech perception difficulties/presbycusis experienced by aging adults.
American Psychological Association (APA)
Chen, Xianming& Liang, Yonghui& Deng, Yihong& Li, Jianzhong& Chen, Shiyan& Wang, Cuixia…[et al.]. 2013. Age-Associated Reduction of Asymmetry in Human Central Auditory Function : A 1H-Magnetic Resonance Spectroscopy Study. Neural Plasticity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-494478
Modern Language Association (MLA)
Chen, Xianming…[et al.]. Age-Associated Reduction of Asymmetry in Human Central Auditory Function : A 1H-Magnetic Resonance Spectroscopy Study. Neural Plasticity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-494478
American Medical Association (AMA)
Chen, Xianming& Liang, Yonghui& Deng, Yihong& Li, Jianzhong& Chen, Shiyan& Wang, Cuixia…[et al.]. Age-Associated Reduction of Asymmetry in Human Central Auditory Function : A 1H-Magnetic Resonance Spectroscopy Study. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-494478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494478