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The Use of Hibiscus esculentus (Okra) Gum in Sustaining the Release of Propranolol Hydrochloride in a Solid Oral Dosage Form
Joint Authors
Kadivar, Ali
Noordin, Mohamed Ibrahim
Zaharuddin, Nurul Dhania
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effectiveness of Okra gum in sustaining the release of propranolol hydrochloride in a tablet was studied.
Okra gum was extracted from the pods of Hibiscus esculentus using acetone as a drying agent.
Dried Okra gum was made into powder form and its physical and chemical characteristics such as solubility, pH, moisture content, viscosity, morphology study using SEM, infrared study using FTIR, crystallinity study using XRD, and thermal study using DSC and TGA were carried out.
The powder was used in the preparation of tablet using granulation and compression methods.
Propranolol hydrochloride was used as a model drug and the activity of Okra gum as a binder was compared by preparing tablets using a synthetic and a semisynthetic binder which are hydroxylmethylpropyl cellulose (HPMC) and sodium alginate, respectively.
Evaluation of drug release kinetics that was attained from dissolution studies showed that Okra gum retarded the release up to 24 hours and exhibited the longest release as compared to HPMC and sodium alginate.
The tensile and crushing strength of tablets was also evaluated by conducting hardness and friability tests.
Okra gum was observed to produce tablets with the highest hardness value and lowest friability.
Hence, Okra gum was testified as an effective adjuvant to produce favourable sustained release tablets with strong tensile and crushing strength.
American Psychological Association (APA)
Zaharuddin, Nurul Dhania& Noordin, Mohamed Ibrahim& Kadivar, Ali. 2014. The Use of Hibiscus esculentus (Okra) Gum in Sustaining the Release of Propranolol Hydrochloride in a Solid Oral Dosage Form. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-494540
Modern Language Association (MLA)
Zaharuddin, Nurul Dhania…[et al.]. The Use of Hibiscus esculentus (Okra) Gum in Sustaining the Release of Propranolol Hydrochloride in a Solid Oral Dosage Form. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-494540
American Medical Association (AMA)
Zaharuddin, Nurul Dhania& Noordin, Mohamed Ibrahim& Kadivar, Ali. The Use of Hibiscus esculentus (Okra) Gum in Sustaining the Release of Propranolol Hydrochloride in a Solid Oral Dosage Form. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-494540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494540