The Evolving Role of Selenium in the Treatment of Graves' Disease and Ophthalmopathy
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Graves' disease (GD) and ophthalmopathy (GO) are organ-specific autoimmune-inflammatory disorders characterized by a complex pathogenesis.
The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of radical oxygen species (ROS), and cytokines which sustain the autoimmune process and perpetuate the disease.
Recently, selenium, which is a powerful antioxidant, has been successfully applied in patients with mild GO, slowing the progression of disease, decreasing the clinical activity score, and appreciably improving the quality of life.
The mechanisms of selenium action are variable.
The aim of this review is to summarize the actions of selenium in GD and GO.
Selenium as selenocysteine is incorporated in selenoproteins, such as glutathione peroxidase which catalyzes the degradation of hydrogen peroxide and lipid hydroperoxide that are increasingly produced in hyperthyroidism.
Moreover, selenium decreases the formation of proinflammatory cytokines, while it contributes, in synergy with antithyroid drugs, to stabilization of the autoimmune process in GD and alleviation of GO.
It is now to be clarified whether enforced nutritional supplementation has the same results and whether prolonging selenium administration may have an impact on the prevention of disease.
American Psychological Association (APA)
Duntas, Leonidas H.. 2012. The Evolving Role of Selenium in the Treatment of Graves' Disease and Ophthalmopathy. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-494571
Modern Language Association (MLA)
Duntas, Leonidas H.. The Evolving Role of Selenium in the Treatment of Graves' Disease and Ophthalmopathy. Journal of Thyroid Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-494571
American Medical Association (AMA)
Duntas, Leonidas H.. The Evolving Role of Selenium in the Treatment of Graves' Disease and Ophthalmopathy. Journal of Thyroid Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-494571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494571