The Effect of Ventilation, Age, and Asthmatic Condition on Ultrafine Particle Deposition in Children
Joint Authors
Cheng, Yung-Sung
Berwick, Marianne
Amaya, Maria A.
Burchiel, Scott W.
Pingitore, Nicholas E.
Olvera, Hector A.
Perez, Daniel
Li, Wen-Whai
Clague, Juan W.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ultrafine particles (UFPs) contribute to health risks associated with air pollution, especially respiratory disease in children.
Nonetheless, experimental data on UFP deposition in asthmatic children has been minimal.
In this study, the effect of ventilation, developing respiratory physiology, and asthmatic condition on the deposition efficiency of ultrafine particles in children was explored.
Deposited fractions of UFP (10–200 nm) were determined in 9 asthmatic children, 8 nonasthmatic children, and 5 nonasthmatic adults.
Deposition efficiencies in adults served as reference of fully developed respiratory physiologies.
A validated deposition model was employed as an auxiliary tool to assess the independent effect of varying ventilation on deposition.
Asthmatic conditions were confirmed via pre-and post-bronchodilator spirometry.
Subjects were exposed to a hygroscopic aerosol with number geometric mean diameter of 27–31 nm, geometric standard deviation of 1.8–2.0, and concentration of 1.2×106 particles cm−3.
Exposure was through a silicone mouthpiece.
Total deposited fraction (TDF) and normalized deposition rate were 50% and 32% higher in children than in adults.
Accounting for tidal volume and age variation, TDF was 21% higher in asthmatic than in non-asthmatic children.
The higher health risks of air pollution exposure observed in children and asthmatics might be augmented by their susceptibility to higher dosages of UFP.
American Psychological Association (APA)
Olvera, Hector A.& Perez, Daniel& Clague, Juan W.& Cheng, Yung-Sung& Li, Wen-Whai& Amaya, Maria A.…[et al.]. 2012. The Effect of Ventilation, Age, and Asthmatic Condition on Ultrafine Particle Deposition in Children. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494582
Modern Language Association (MLA)
Olvera, Hector A.…[et al.]. The Effect of Ventilation, Age, and Asthmatic Condition on Ultrafine Particle Deposition in Children. Pulmonary Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-494582
American Medical Association (AMA)
Olvera, Hector A.& Perez, Daniel& Clague, Juan W.& Cheng, Yung-Sung& Li, Wen-Whai& Amaya, Maria A.…[et al.]. The Effect of Ventilation, Age, and Asthmatic Condition on Ultrafine Particle Deposition in Children. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494582