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Stem Cells as a Tool to Improve Outcomes of Islet Transplantation
Joint Authors
Sims, Emily
Evans-Molina, Carmella
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The publication of the promising results of the Edmonton protocol in 2000 generated optimism for islet transplantation as a potential cure for Type 1 Diabetes Mellitus.
Unfortunately, follow-up data revealed that less than 10% of patients achieved long-term insulin independence.
More recent data from other large trials like the Collaborative Islet Transplant Registry show incremental improvement with 44% of islet transplant recipients maintaining insulin independence at three years of follow-up.
Multiple underlying issues have been identified that contribute to islet graft failure, and newer research has attempted to address these problems.
Stem cells have been utilized not only as a functional replacement for β cells, but also as companion or supportive cells to address a variety of different obstacles that prevent ideal graft viability and function.
In this paper, we outline the manners in which stem cells have been applied to address barriers to the achievement of long-term insulin independence following islet transplantation.
American Psychological Association (APA)
Sims, Emily& Evans-Molina, Carmella. 2012. Stem Cells as a Tool to Improve Outcomes of Islet Transplantation. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494612
Modern Language Association (MLA)
Sims, Emily& Evans-Molina, Carmella. Stem Cells as a Tool to Improve Outcomes of Islet Transplantation. Journal of Transplantation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-494612
American Medical Association (AMA)
Sims, Emily& Evans-Molina, Carmella. Stem Cells as a Tool to Improve Outcomes of Islet Transplantation. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494612