Double-Blinded, Vehicle-Controlled Proof of Concept Study to Investigate the Recurrence of Inflammatory and Noninflammatory Acne Lesions Using Tretinoin Gel (Microsphere) 0.04% in Male Patients after Oral Isotretinoin Use
Joint Authors
Source
Dermatology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Although isotretinoin orally is commonly used for moderate to severe or scarring acne, it is not a cure.
Unfortunately recurrence is unpredictable and varies within the acne population.
Objectives.
Using a proof of concept study, determine the recurrence of acne after isotretinoin use in male patients.
Methods.
Twenty males aged 18–45 years old were enrolled.
Subjects successfully completed a treatment of acne vulgaris with oral isotretinoin (120–150 mg/kg/course).
Subjects were randomized 1 to 1.
The study duration was 24 weeks.
The primary endpoint measured was the absolute change in lesion counts from baseline to weeks 16 and 24.
Local tolerability assessments were measured.
Results.
There were favorable changes in all outcomes measured.
Overall, there was a 38.7% lower lesion count with tretinoin 0.04% microsphere gel use versus vehicle.
The active product was well tolerated with great patient satisfaction.
There were no significant safety issues.
The limitations included the low number of patients enrolled, average age, and percentage of patients lost to follow-up.
Conclusion.
In summary, the results favored tretinoin 0.04% microsphere gel in the prevention of recurrent acne after isotretinoin use in male patients over 18 years old over a six-month period.
American Psychological Association (APA)
Vender, Reid& Vender, Ronald. 2012. Double-Blinded, Vehicle-Controlled Proof of Concept Study to Investigate the Recurrence of Inflammatory and Noninflammatory Acne Lesions Using Tretinoin Gel (Microsphere) 0.04% in Male Patients after Oral Isotretinoin Use. Dermatology Research and Practice،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-494616
Modern Language Association (MLA)
Vender, Reid& Vender, Ronald. Double-Blinded, Vehicle-Controlled Proof of Concept Study to Investigate the Recurrence of Inflammatory and Noninflammatory Acne Lesions Using Tretinoin Gel (Microsphere) 0.04% in Male Patients after Oral Isotretinoin Use. Dermatology Research and Practice No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-494616
American Medical Association (AMA)
Vender, Reid& Vender, Ronald. Double-Blinded, Vehicle-Controlled Proof of Concept Study to Investigate the Recurrence of Inflammatory and Noninflammatory Acne Lesions Using Tretinoin Gel (Microsphere) 0.04% in Male Patients after Oral Isotretinoin Use. Dermatology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-494616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494616