Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis : A Cross-Sectional Study in a Mexican Population
Joint Authors
Martín-Márquez, Beatriz Teresita
Gómez-Bañuelos, Eduardo
Navarro-Hernandez, Rosa Elena
Madrigal-Ruiz, Perla Monserrat
Figueroa-Sanchez, Mauricio
Martínez-García, Erika Aurora
Saldaña-Millan, Adan Alberto
Duran-Barragan, Sergio
Gonzalez-Lopez, Laura
Vázquez-Del Mercado, Mónica
Nuñez-Atahualpa, Lourdes
Gamez-Nava, Jorge Ivan
Rocha-Muñoz, Alberto Daniel
Sánchez-Hernández, Pedro Ernesto
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Patients with rheumatoid arthritis (RA) have a higher risk for atherosclerosis.
There is no clinical information about scavenger receptor CD36 and the development of subclinical atherosclerosis in patients with RA.
The aim of this study was to evaluate the association between membrane expression of CD36 in peripheral blood mononuclear cells (PBMC) and carotid intima-media thickness (cIMT) in patients with RA.
Methods.
We included 67 patients with RA from the Rheumatology Department of Hospital Civil “Dr.
Juan I.
Menchaca,” Guadalajara, Jalisco, Mexico.
We evaluated the cIMT, considering subclinical atherosclerosis when >0.6 mm.
Since our main objective was to associate the membrane expression of CD36 with subclinical atherosclerosis, other molecules related with cardiovascular risk such as ox-LDL, IL-6, and TNFα were tested.
Results.
We found low CD36 membrane expression in PBMC from RA patients with subclinical atherosclerosis (P<0.001).
CD36 mean fluorescence intensity had negative correlations with cIMT (r = −0.578, P<0.001), ox-LDL (r = −0.427, P = 0.05), TNFα (r = −0.729, P<0.001), and IL-6 (r = −0.822, P<0.001).
Conclusion.
RA patients with subclinical atherosclerosis showed low membrane expression of CD36 in PBMC and increased serum proinflammatory cytokines.
Further studies are needed to clarify the regulation of CD36 in RA.
American Psychological Association (APA)
Gómez-Bañuelos, Eduardo& Martín-Márquez, Beatriz Teresita& Martínez-García, Erika Aurora& Figueroa-Sanchez, Mauricio& Nuñez-Atahualpa, Lourdes& Rocha-Muñoz, Alberto Daniel…[et al.]. 2014. Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis : A Cross-Sectional Study in a Mexican Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-494631
Modern Language Association (MLA)
Gómez-Bañuelos, Eduardo…[et al.]. Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis : A Cross-Sectional Study in a Mexican Population. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-494631
American Medical Association (AMA)
Gómez-Bañuelos, Eduardo& Martín-Márquez, Beatriz Teresita& Martínez-García, Erika Aurora& Figueroa-Sanchez, Mauricio& Nuñez-Atahualpa, Lourdes& Rocha-Muñoz, Alberto Daniel…[et al.]. Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis : A Cross-Sectional Study in a Mexican Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-494631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494631