Computational Evidence of NAGNAG Alternative Splicing in Human Large Intergenic Noncoding RNA
Joint Authors
Yan, Xiaoyan
Sun, Xiaoyong
Lin, Simon M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
NAGNAG alternative splicing plays an essential role in biological processes and represents a highly adaptable system for posttranslational regulation of gene function.
NAGNAG alternative splicing impacts a myriad of biological processes.
Previous studies of NAGNAG largely focused on messenger RNA.
To the best of our knowledge, this is the first study testing the hypothesis that NAGNAG alternative splicing is also operative in large intergenic noncoding RNA (lincRNA).
The RNA-seq data sets from recent deep sequencing studies were queried to test our hypothesis.
NAGNAG alternative splicing of human lincRNA was identified while querying two independent RNA-seq data sets.
Within these datasets, 31 NAGNAG alternative splicing sites were identified in lincRNA.
Notably, most exons of lincRNA containing NAGNAG acceptors were longer than those from protein-coding genes.
Furthermore, presence of CAG coding appeared to participate in the splice site selection.
Finally, expression of the isoforms of NAGNAG lincRNA exhibited tissue specificity.
Together, this study improves our understanding of the NAGNAG alternative splicing in lincRNA.
American Psychological Association (APA)
Sun, Xiaoyong& Lin, Simon M.& Yan, Xiaoyan. 2014. Computational Evidence of NAGNAG Alternative Splicing in Human Large Intergenic Noncoding RNA. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494635
Modern Language Association (MLA)
Sun, Xiaoyong…[et al.]. Computational Evidence of NAGNAG Alternative Splicing in Human Large Intergenic Noncoding RNA. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-494635
American Medical Association (AMA)
Sun, Xiaoyong& Lin, Simon M.& Yan, Xiaoyan. Computational Evidence of NAGNAG Alternative Splicing in Human Large Intergenic Noncoding RNA. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-494635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494635