Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity
Joint Authors
Osmenda, Grzegorz
Kwaśny-Krochin, Beata
Wizner, Barbara
Klimek, Ewa
Skalska, Anna
Guzik, Tomasz
Grodzicki, Tomasz K.
Korkosz, Mariusz
Mikołajczyk, Tomasz
Sulicka, Joanna
Surdacki, Andrzej
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
To evaluate blood monocyte subsets and functional monocyte properties in patients with rheumatoid arthritis (RA) of short duration in the context of cardiovascular (CV) risk and disease activity.
Methods.
We studied conventional markers of CV risk, intima media thickness (IMT), and blood monocyte subsets in 27 patients aged 41 ± 10 years with RA of short duration (median 12 months) and 22 healthy controls.
The RA subjects were divided into low (DAS28: 2.6–5.1) and high (DAS28 > 5.1) disease activity.
Results.
RA patients exhibited increased levels of intermediate (CD14++CD16+) monocytes with decreased CD45RA expression compared to controls, increased counts of classical (CD14++CD16−) monocytes, and decreased percentages of nonclassical (CD14+CD16++) monocytes.
Patients with high disease activity had lower HLA DR expression on classical monocytes compared to low disease activity patients.
There were no differences in monocyte subsets between subjects with DAS > 5.1 and DAS ≤ 5.1.
There were no significant intergroup differences in IMT and the majority of classical CV risk factors.
Conclusions.
Patients with RA of short duration show alteration in peripheral blood monocyte subsets despite the fact that there is no evidence of subclinical atherosclerosis.
Disease activity assessed with DAS28 was associated with impaired functional properties but not with a shift in monocyte subpopulations.
American Psychological Association (APA)
Klimek, Ewa& Mikołajczyk, Tomasz& Sulicka, Joanna& Kwaśny-Krochin, Beata& Korkosz, Mariusz& Osmenda, Grzegorz…[et al.]. 2014. Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-494640
Modern Language Association (MLA)
Klimek, Ewa…[et al.]. Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-494640
American Medical Association (AMA)
Klimek, Ewa& Mikołajczyk, Tomasz& Sulicka, Joanna& Kwaśny-Krochin, Beata& Korkosz, Mariusz& Osmenda, Grzegorz…[et al.]. Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-494640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494640