Aggrephagy : Selective Disposal of Protein Aggregates by Macroautophagy
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Protein aggregation is a continuous process in our cells.
Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors.
The decision to form an aggregate is largely made by chaperones and chaperone-assisted proteins.
Proteins that are damaged beyond repair are degraded either by the proteasome or by the lysosome via autophagy.
The aggregates can be degraded by the proteasome and by chaperone-mediated autophagy only after dissolution into soluble single peptide species.
Hence, protein aggregates as such are degraded by macroautophagy.
The selective degradation of protein aggregates by macroautophagy is called aggrephagy.
Here we review the processes of aggregate formation, recognition, transport, and sequestration into autophagosomes by autophagy receptors and the role of aggrephagy in different protein aggregation diseases.
American Psychological Association (APA)
Lamark, Trond& Johansen, Terje. 2012. Aggrephagy : Selective Disposal of Protein Aggregates by Macroautophagy. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-494646
Modern Language Association (MLA)
Lamark, Trond& Johansen, Terje. Aggrephagy : Selective Disposal of Protein Aggregates by Macroautophagy. International Journal of Cell Biology No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-494646
American Medical Association (AMA)
Lamark, Trond& Johansen, Terje. Aggrephagy : Selective Disposal of Protein Aggregates by Macroautophagy. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-494646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494646