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Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
Joint Authors
Manabe, Yukari C.
Kamya, Moses R.
Sempa, Joseph
Agnes, Kiragga N.
Castelnuovo, Barbara
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia.
Methods.
In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-suppression: (VL ≤1,000 copies/mL) (2) VL 1,001–10,000, or (3) VL >10,000.
Results.
Fifty-Three (11.2%) and 84 (17.8%) patients had a first episode of intermediate and high viremia, respectively.
Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (P<.001).
The majority of patients with viremia achieved viral suppression when the measurement was repeated.
Only 39.6% of patients with intermediate and 19.1% with high viremia eventually needed to be switched to second line (P=.008).
Conclusions.
The use of at least one repeat measurement rather than a single VL measurement could avert from 60% to 80% of unnecessary switches.
American Psychological Association (APA)
Castelnuovo, Barbara& Sempa, Joseph& Agnes, Kiragga N.& Kamya, Moses R.& Manabe, Yukari C.. 2011. Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494650
Modern Language Association (MLA)
Castelnuovo, Barbara…[et al.]. Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings. AIDS Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494650
American Medical Association (AMA)
Castelnuovo, Barbara& Sempa, Joseph& Agnes, Kiragga N.& Kamya, Moses R.& Manabe, Yukari C.. Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings. AIDS Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494650