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AngiotensinII Preconditioning Promotes Angiogenesis In Vitro via ERKs Phosphorylation
Joint Authors
Qian, Sanli
Gong, Hui
Ge, Junbo
Zou, Yunzeng
Zhang, Guoping
Ye, Yong
Jia, Jianguo
Guan, Aili
Niu, Yuhong
Li, Bingyu
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
AngiotensinII (AngII) is involved in not only the formation of cardiac hypertrophy but also the development of cardiac remodeling both of which are associated with myocardial angiogenesis.
This study was therefore performed to clarify the effects of AngII on the formation of vasculatures by cultured cardiac microvascular endothelial cells (CMVECs) after a long-period stimulation with or without the AngII preconditioning.
Incubation with AngII for 18 hrs significantly impaired the formation of capillary-like tubes comparing to that without AngII.
CMVECs with AngII pretreatment for 5 and 10 min formed more capillary-like tubes than those without AngII pretreatment, suggesting that preconditioning with AngII at a lower dose for a short period could prevent the further damage of CMVECs by a higher concentration of AngII.
Moreover, AngII (10-7 M) stimulation for 5 and 10 min significantly induced the increase in extracellular signal-regulated protein kinases (ERKs) phosphorylation, and an ERKs inhibitor, PD98059, abrogated the increase in the formation of capillary-like tubes induced by the AngII-pretreatment.
In conclusion, preconditioning with a lower concentration of AngII for a short period prevents the subsequent impairment of CMVECs by a higher dose of AngII, at least in part, through the increase in ERKs phosphorylation.
American Psychological Association (APA)
Guan, Aili& Zou, Yunzeng& Gong, Hui& Niu, Yuhong& Ye, Yong& Jia, Jianguo…[et al.]. 2012. AngiotensinII Preconditioning Promotes Angiogenesis In Vitro via ERKs Phosphorylation. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-494664
Modern Language Association (MLA)
Guan, Aili…[et al.]. AngiotensinII Preconditioning Promotes Angiogenesis In Vitro via ERKs Phosphorylation. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-494664
American Medical Association (AMA)
Guan, Aili& Zou, Yunzeng& Gong, Hui& Niu, Yuhong& Ye, Yong& Jia, Jianguo…[et al.]. AngiotensinII Preconditioning Promotes Angiogenesis In Vitro via ERKs Phosphorylation. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-494664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494664