Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection
Joint Authors
Cuervo, Henar
Fresno, Manuel
Gea, Susana
Gironès, Núria
Carrera-Silva, Eugenio Antonio
Aoki, Maria Pilar
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chagas myocarditis, which is caused by infection with the intracellular parasite Trypanosoma cruzi, remains the major infectious heart disease worldwide.
Innate recognition through toll-like receptors (TLRs) on immune cells has not only been revealed to be critical for defense against T.
cruzi but has also been involved in triggering the pathology.
Subsequent studies revealed that this parasite activates nucleotide-binding oligomerization domain- (NOD-)like receptors and several particular transcription factors in TLR-independent manner.
In addition to professional immune cells, T.
cruzi infects and resides in different parenchyma cells.
The innate receptors in nonimmune target tissues could also have an impact on host response.
Thus, the outcome of the myocarditis or the inflamed liver relies on an intricate network of inflammatory mediators and signals given by immune and nonimmune cells.
In this paper, we discuss the evidence of innate immunity to the parasite developed by the host, with emphasis on the crosstalk between immune and nonimmune cell responses.
American Psychological Association (APA)
Aoki, Maria Pilar& Carrera-Silva, Eugenio Antonio& Cuervo, Henar& Fresno, Manuel& Gironès, Núria& Gea, Susana. 2011. Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494676
Modern Language Association (MLA)
Aoki, Maria Pilar…[et al.]. Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection. Journal of Parasitology Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-494676
American Medical Association (AMA)
Aoki, Maria Pilar& Carrera-Silva, Eugenio Antonio& Cuervo, Henar& Fresno, Manuel& Gironès, Núria& Gea, Susana. Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection. Journal of Parasitology Research. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494676