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Anticancer Effects of Geopropolis Produced by Stingless Bees on Canine Osteosarcoma Cells In Vitro
Joint Authors
Araújo, Maria José Abigail Mendes
Bersano, Paulo Ricardo Oliveira
Sforcin, José Maurício
Búfalo, Michelle Cristiane
Cinegaglia, Naiara Costa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Geopropolis is produced by indigenous stingless bees from the resinous material of plants, adding soil or clay.
Its biological properties have not been investigated, such as propolis, and herein its cytotoxic action on canine osteosarcoma (OSA) cells was evaluated.
OSA is a primary bone neoplasm diagnosed in dogs being an excellent model in vivo to study human OSA.
spOS-2 primary cultures were isolated from the tumor of a dog with osteosarcoma and incubated with geopropolis, 70% ethanol (geopropolis solvent), and carboplatin after 6, 24, 48, and 72 hours.
Cell viability was analyzed by the crystal violet method.
Geopropolis was efficient against canine OSA cells in a dose- and time-dependent way, leading to a distinct morphology compared to control.
Geopropolis cytotoxic action was exclusively due to its constituents since 70% ethanol (its solvent) had no effect on cell viability.
Carboplatin had no effect on OSA cells.
Geopropolis exerted a cytotoxic effect on canine osteosarcoma, and its introduction as a possible therapeutic agent in vivo could be investigated, providing a new contribution to OSA treatment.
American Psychological Association (APA)
Cinegaglia, Naiara Costa& Bersano, Paulo Ricardo Oliveira& Araújo, Maria José Abigail Mendes& Búfalo, Michelle Cristiane& Sforcin, José Maurício. 2013. Anticancer Effects of Geopropolis Produced by Stingless Bees on Canine Osteosarcoma Cells In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-494678
Modern Language Association (MLA)
Cinegaglia, Naiara Costa…[et al.]. Anticancer Effects of Geopropolis Produced by Stingless Bees on Canine Osteosarcoma Cells In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-494678
American Medical Association (AMA)
Cinegaglia, Naiara Costa& Bersano, Paulo Ricardo Oliveira& Araújo, Maria José Abigail Mendes& Búfalo, Michelle Cristiane& Sforcin, José Maurício. Anticancer Effects of Geopropolis Produced by Stingless Bees on Canine Osteosarcoma Cells In Vitro. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-494678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494678