![](/images/graphics-bg.png)
Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications
Joint Authors
Enfield, Katey S. S.
Pikor, Larissa A.
Lam, Wan L.
Martinez, Victor D.
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Lung cancer biology has traditionally focused on genomic and epigenomic deregulation of protein-coding genes to identify oncogenes and tumor suppressors diagnostic and therapeutic targets.
Another important layer of cancer biology has emerged in the form of noncoding RNAs (ncRNAs), which are major regulators of key cellular processes such as proliferation, RNA splicing, gene regulation, and apoptosis.
In the past decade, microRNAs (miRNAs) have moved to the forefront of ncRNA cancer research, while the role of long noncoding RNAs (lncRNAs) is emerging.
Here we review the mechanisms by which miRNAs and lncRNAs are deregulated in lung cancer, the technologies that can be applied to detect such alterations, and the clinical potential of these RNA species.
An improved comprehension of lung cancer biology will come through the understanding of the interplay between deregulation of non-coding RNAs, the protein-coding genes they regulate, and how these interactions influence cellular networks and signalling pathways.
American Psychological Association (APA)
Enfield, Katey S. S.& Pikor, Larissa A.& Martinez, Victor D.& Lam, Wan L.. 2012. Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genetics Research International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-494683
Modern Language Association (MLA)
Enfield, Katey S. S.…[et al.]. Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genetics Research International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-494683
American Medical Association (AMA)
Enfield, Katey S. S.& Pikor, Larissa A.& Martinez, Victor D.& Lam, Wan L.. Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-494683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494683