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Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial IschemiaReperfusion Injury
Joint Authors
Attmann, Tim
Braesen, Jan
Hagemann, Angelika
Grothusen, Christina
Broch, Ole
Schoettler, Jan
Cremer, Jochen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Revascularization of infarcted myocardium results in release of inflammatory cytokines mediating myocardial reperfusion injury and heart failure.
Blockage of inflammatory pathways dampens myocardial injury and reduces infarct size.
We compared the impact of the interleukin-1 receptor antagonist Anakinra and erythropoietin on myocardial ischemia/reperfusion injury.
In contrast to others, we hypothesized that drug administration prior to reperfusion reduces myocardial damage.
Methods and Results.
12–15 week-old Lewis rats were subjected to myocardial ischemia by a 1 hr occlusion of the left anterior descending coronary artery.
After 15 min of ischemia, a single shot of Anakinra (2 mg/kg body weight (bw)) or erythropoietin (5000 IE/kg bw) was administered intravenously.
In contrast to erythropoietin, Anakinra decreased infarct size (P<0.05, N=4/group) and troponin T levels (P<0.05, N=4/group).
Conclusion.
One-time intravenous administration of Anakinra prior to myocardial reperfusion reduces infarct size in experimental ischemia/reperfusion injury.
Thus, Anakinra may represent a treatment option in myocardial infarction prior to revascularization.
American Psychological Association (APA)
Grothusen, Christina& Hagemann, Angelika& Attmann, Tim& Braesen, Jan& Broch, Ole& Cremer, Jochen…[et al.]. 2012. Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial IschemiaReperfusion Injury. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-494698
Modern Language Association (MLA)
Grothusen, Christina…[et al.]. Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial IschemiaReperfusion Injury. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-494698
American Medical Association (AMA)
Grothusen, Christina& Hagemann, Angelika& Attmann, Tim& Braesen, Jan& Broch, Ole& Cremer, Jochen…[et al.]. Impact of an Interleukin-1 Receptor Antagonist and Erythropoietin on Experimental Myocardial IschemiaReperfusion Injury. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-494698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494698