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NRF2-ome : An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2
Joint Authors
Türei, Dénes
Fazekas, Dávid
Módos, Dezső
Földvári-Nagy, László
Korcsmáros, Tamás
Papp, Diána
Csermely, Péter
Lenti, Katalin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
NRF2 is the master transcriptional regulator of oxidative and xenobiotic stress responses.
NRF2 has important roles in carcinogenesis, inflammation, and neurodegenerative diseases.
We developed an online resource, NRF2-ome, to provide an integrated and systems-level database for NRF2.
The database contains manually curated and predicted interactions of NRF2 as well as data from external interaction databases.
We integrated NRF2 interactome with NRF2 target genes, NRF2 regulating TFs, and miRNAs.
We connected NRF2-ome to signaling pathways to allow mapping upstream NRF2 regulatory components that could directly or indirectly influence NRF2 activity totaling 35,967 protein-protein and signaling interactions.
The user-friendly website allows researchers without computational background to search, browse, and download the database.
The database can be downloaded in SQL, CSV, BioPAX, SBML, PSI-MI, and in a Cytoscape CYS file formats.
We illustrated the applicability of the website by suggesting a posttranscriptional negative feedback of NRF2 by MAFG protein and raised the possibility of a connection between NRF2 and the JAK/STAT pathway through STAT1 and STAT3.
NRF2-ome can also be used as an evaluation tool to help researchers and drug developers to understand the hidden regulatory mechanisms in the complex network of NRF2.
American Psychological Association (APA)
Türei, Dénes& Papp, Diána& Fazekas, Dávid& Földvári-Nagy, László& Módos, Dezső& Lenti, Katalin…[et al.]. 2013. NRF2-ome : An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494700
Modern Language Association (MLA)
Türei, Dénes…[et al.]. NRF2-ome : An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-494700
American Medical Association (AMA)
Türei, Dénes& Papp, Diána& Fazekas, Dávid& Földvári-Nagy, László& Módos, Dezső& Lenti, Katalin…[et al.]. NRF2-ome : An Integrated Web Resource to Discover Protein Interaction and Regulatory Networks of NRF2. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494700