The Biphasic Role of Microglia in Alzheimer's Disease
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neuroinflammation is involved in the pathogenesis of Alzheimer's disease (AD).
Microglia, macrophage-like resident immune cells in the brain, play critical roles in the inflammatory aspects of AD.
Microglia may be activated by oligomeric and fibrillar species of amyloid β (Aβ) that are constituents of senile plaques and by molecules derived from degenerated neurons, such as purines and chemokines, which enhance their migration and phagocytosis.
The main neurotoxic molecules produced by activated microglia may be reactive oxygen species, glutamate, and inflammatory cytokines such as tumor-necrosis-factor-α and interleukin- (IL-) 1β These molecules differentially induce neurotoxicity.
Aβ itself directly damages neurons.
In terms of neuroprotective properties, microglia treated with fractalkine or IL-34 attenuate Aβ neurotoxicity by Aβ clearance and the production of antioxidants.
Therefore, regulation of the microglial role in neuroprotection may be a useful therapeutic strategy for AD.
American Psychological Association (APA)
Mizuno, Tetsuya. 2012. The Biphasic Role of Microglia in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494710
Modern Language Association (MLA)
Mizuno, Tetsuya. The Biphasic Role of Microglia in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-494710
American Medical Association (AMA)
Mizuno, Tetsuya. The Biphasic Role of Microglia in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494710