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Influence of Epinastine Hydrochloride, an H1-Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo
Joint Authors
Suzaki, Harumi
Asano, Kazuhito
Kanai, Ken-Ichi
Suzuki, Miyuki
Oshima, Ken-Zaburo
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There is established concept that dendritic cells (DCs) play essential roles in the development of allergic immune responses.
However, the influence of H1 receptor antagonists on DC functions is not well defined.
The aim of the present study was to examine the effect of epinastine hydrochloride (EP), the most notable histamine H1 receptor antagonists in Japan, on Dermatophagoides farinae (Der f)-pulsed mouse bone marrow-derived DCs in vitro and in vivo.
EP at more than 25 ng/mL could significantly inhibit the production of IL-6, TNF-α and IL-10 from Der f-pulsed DCs, which was increased by Der f challenge in vitro.
On the other hand, EP increased the ability of Der f-pulsed DCs to produce IL-12.
Intranasal instillation of Der f-pulsed DCs resulted in nasal eosinophilia associated with a significant increase in IL-5 levels in nasal lavage fluids.
Der f-pulsed and EP-treated DCs significantly inhibited nasal eosinophila and reduced IL-5.
These results indicate that EP inhibits the development of Th2 immune responses through the modulation of DC functions and results in favorable modification of clinical status of allergic diseases.
American Psychological Association (APA)
Oshima, Ken-Zaburo& Asano, Kazuhito& Kanai, Ken-Ichi& Suzuki, Miyuki& Suzaki, Harumi. 2009. Influence of Epinastine Hydrochloride, an H1-Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-494721
Modern Language Association (MLA)
Oshima, Ken-Zaburo…[et al.]. Influence of Epinastine Hydrochloride, an H1-Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo. Mediators of Inflammation No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-494721
American Medical Association (AMA)
Oshima, Ken-Zaburo& Asano, Kazuhito& Kanai, Ken-Ichi& Suzuki, Miyuki& Suzaki, Harumi. Influence of Epinastine Hydrochloride, an H1-Receptor Antagonist, on the Function of Mite Allergen-Pulsed Murine Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-494721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494721