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Integrin Signaling, Cell Survival, and Anoikis : Distinctions, Differences, and Differentiation
Author
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-13
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Cell survival and apoptosis implicate an increasing complexity of players and signaling pathways which regulate not only the decision-making process of surviving (or dying), but as well the execution of cell death proper.
The same complex nature applies to anoikis, a form of caspase-dependent apoptosis that is largely regulated by integrin-mediated, cell-extracellular matrix interactions.
Not surprisingly, the regulation of cell survival, apoptosis, and anoikis furthermore implicates additional mechanistic distinctions according to the specific tissue, cell type, and species.
Incidentally, studies in recent years have unearthed yet another layer of complexity in the regulation of these cell processes, namely, the implication of cell differentiation state-specific mechanisms.
Further analyses of such differentiation state-distinct mechanisms, either under normal or physiopathological contexts, should increase our understanding of diseases which implicate a deregulation of integrin function, cell survival, and anoikis.
American Psychological Association (APA)
Vachon, Pierre H.. 2011. Integrin Signaling, Cell Survival, and Anoikis : Distinctions, Differences, and Differentiation. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-494731
Modern Language Association (MLA)
Vachon, Pierre H.. Integrin Signaling, Cell Survival, and Anoikis : Distinctions, Differences, and Differentiation. Journal of Signal Transduction No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-494731
American Medical Association (AMA)
Vachon, Pierre H.. Integrin Signaling, Cell Survival, and Anoikis : Distinctions, Differences, and Differentiation. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-494731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494731