Methoxy-Poly(ethylene glycol) Modified Poly(L-lactide) Enhanced Cell Affinity of Human Bone Marrow Stromal Cells by the Upregulation of 1-Cadherin and Delta-2-catenin
Joint Authors
Quan, Jingjing
Mao, Xueli
Xiao, Yin
Peng, Hui
Chen, Zetao
Ling, Junqi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Poly(l-lactide) (PLLA), a versatile biodegradable polymer, is one of the most commonly-used materials for tissue engineering applications.
To improve cell affinity for PLLA, poly(ethylene glycol) (PEG) was used to develop diblock copolymers.
Human bone marrow stromal cells (hBMSCs) were cultured on MPEG-b-PLLA copolymer films to determine the effects of modification on the attachment and proliferation of hBMSC.
The mRNA expression of 84 human extracellular matrix (ECM) and adhesion molecules was analyzed using RT-qPCR to understand the underlying mechanisms.
It was found that MPEG-b-PLLA copolymer films significantly improved cell adhesion, extension, and proliferation.
This was found to be related to the significant upregulation of two adhesion genes, CDH1 and CTNND2, which encode 1-cadherin and delta-2-catenin, respectively, two key components for the cadherin-catenin complex.
In summary, MPEG-b-PLLA copolymer surfaces improved initial cell adhesion by stimulation of adhesion molecule gene expression.
American Psychological Association (APA)
Mao, Xueli& Chen, Zetao& Ling, Junqi& Quan, Jingjing& Peng, Hui& Xiao, Yin. 2014. Methoxy-Poly(ethylene glycol) Modified Poly(L-lactide) Enhanced Cell Affinity of Human Bone Marrow Stromal Cells by the Upregulation of 1-Cadherin and Delta-2-catenin. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-494741
Modern Language Association (MLA)
Mao, Xueli…[et al.]. Methoxy-Poly(ethylene glycol) Modified Poly(L-lactide) Enhanced Cell Affinity of Human Bone Marrow Stromal Cells by the Upregulation of 1-Cadherin and Delta-2-catenin. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-494741
American Medical Association (AMA)
Mao, Xueli& Chen, Zetao& Ling, Junqi& Quan, Jingjing& Peng, Hui& Xiao, Yin. Methoxy-Poly(ethylene glycol) Modified Poly(L-lactide) Enhanced Cell Affinity of Human Bone Marrow Stromal Cells by the Upregulation of 1-Cadherin and Delta-2-catenin. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-494741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494741