Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

Abstract EN

Dendritic cells (DCs) are highly efficient antigen-presenting cells.

The migratory properties of DCs give them the capacity to be a sentinel of the body and the vital role in the induction and regulation of adaptive immune responses.

Therefore, it is important to understand the mechanisms in control of migration of DCs to lymphoid and nonlymphoid tissues.

This may provide us novel insight into the clinical treatment of diseases such as autoimmune disease, infectious disease, and tumor.

The chemotactic G protein-coupled receptors (GPCR) play a vital role in control of DCs migration.

Here, we reviewed the recent advances regarding the role of GPCR in control of migration of subsets of DCs, with a focus on the chemokine receptors.

Understanding subsets of DCs migration could provide a rational basis for the design of novel therapies in various clinical conditions.