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Endometrial Cancer and Hypermethylation : Regulation of DNA and MicroRNA by Epigenetics
Joint Authors
Ueki, Arisa
Aoki, Daisuke
Kobayashi, Yusuke
Kisu, Iori
Yanokura, Megumi
Banno, Kouji
Tsuji, Kosuke
Susumu, Nobuyuki
Yamagami, Wataru
Nomura, Hiroyuki
Masuda, Kenta
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Endometrial cancer is the seventh most common cancer in women worldwide.
Therefore elucidation of the pathogenesis and development of effective treatment for endometrial cancer are important.
However, several aspects of the mechanism of carcinogenesis in the endometrium remain unclear.
Associations with genetic variation and mutations of cancer-related genes have been shown, but these do not provide a complete explanation.
Therefore, in recent years, epigenetic mechanisms that do not involve changes in DNA sequences have been examined.
Studies aimed at detection of aberrant DNA hypermethylation in cancer cells present in microscopic amounts in vivo and application of the results to cancer diagnosis have also started.
Breakdown of the DNA mismatch repair mechanism is thought to play a large role in the development of endometrial cancer, with changes in the expression of the hMLH1 gene being particularly important.
Silencing of genes such as APC and CHFR, Sprouty 2, RASSF1A, GPR54, CDH1, and RSK4 by DNA hypermethylation, onset of Lynch syndrome due to hereditary epimutation of hMLH1 and hMSH2 mismatch repair genes, and regulation of gene expression by microRNAs may also underlie the carcinogenic mechanisms of endometrial cancer.
Further understanding of these issues may permit development of new therapies.
American Psychological Association (APA)
Banno, Kouji& Kisu, Iori& Yanokura, Megumi& Masuda, Kenta& Kobayashi, Yusuke& Ueki, Arisa…[et al.]. 2012. Endometrial Cancer and Hypermethylation : Regulation of DNA and MicroRNA by Epigenetics. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-494748
Modern Language Association (MLA)
Banno, Kouji…[et al.]. Endometrial Cancer and Hypermethylation : Regulation of DNA and MicroRNA by Epigenetics. Biochemistry Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-494748
American Medical Association (AMA)
Banno, Kouji& Kisu, Iori& Yanokura, Megumi& Masuda, Kenta& Kobayashi, Yusuke& Ueki, Arisa…[et al.]. Endometrial Cancer and Hypermethylation : Regulation of DNA and MicroRNA by Epigenetics. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-494748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494748