Computational Methods to Work as First-Pass Filter in Deleterious SNP Analysis of Alkaptonuria
Joint Authors
Priya Doss, C. George
Magesh, R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
A major challenge in the analysis of human genetic variation is to distinguish functional from nonfunctional SNPs.
Discovering these functional SNPs is one of the main goals of modern genetics and genomics studies.
There is a need to effectively and efficiently identify functionally important nsSNPs which may be deleterious or disease causing and to identify their molecular effects.
The prediction of phenotype of nsSNPs by computational analysis may provide a good way to explore the function of nsSNPs and its relationship with susceptibility to disease.
In this context, we surveyed and compared variation databases along with in silico prediction programs to assess the effects of deleterious functional variants on protein functions.
In other respects, we attempted these methods to work as first-pass filter to identify the deleterious substitutions worth pursuing for further experimental research.
In this analysis, we used the existing computational methods to explore the mutation-structure-function relationship in HGD gene causing alkaptonuria.
American Psychological Association (APA)
Magesh, R.& Priya Doss, C. George. 2012. Computational Methods to Work as First-Pass Filter in Deleterious SNP Analysis of Alkaptonuria. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494766
Modern Language Association (MLA)
Magesh, R.& Priya Doss, C. George. Computational Methods to Work as First-Pass Filter in Deleterious SNP Analysis of Alkaptonuria. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-494766
American Medical Association (AMA)
Magesh, R.& Priya Doss, C. George. Computational Methods to Work as First-Pass Filter in Deleterious SNP Analysis of Alkaptonuria. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494766