![](/images/graphics-bg.png)
UPR-Mediated Membrane Biogenesis in B Cells
Joint Authors
Brewer, Joseph W.
Jackowski, Suzanne
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The unfolded protein response (UPR) can coordinate the regulation of gene transcription and protein translation to balance the load of client proteins with the protein folding and degradative capacities of the ER.
Increasing evidence also implicates the UPR in the regulation of lipid synthesis and membrane biogenesis.
The differentiation of B lymphocytes into antibody-secreting cells is marked by significant expansion of the ER, the site for antibody synthesis and assembly.
In activated B cells, the demand for membrane protein and lipid components leads to activation of the UPR transcriptional activator XBP1(S) which, in turn, initiates a cascade of biochemical events that enhance supplies of phospholipid precursors and build machinery for the synthesis, maturation, and transport of secretory proteins.
The alterations in lipid metabolism that occur during this developmental transition and the impact of membrane phospholipid restriction on B cell secretory characteristics are discussed in this paper.
American Psychological Association (APA)
Brewer, Joseph W.& Jackowski, Suzanne. 2011. UPR-Mediated Membrane Biogenesis in B Cells. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-494771
Modern Language Association (MLA)
Brewer, Joseph W.& Jackowski, Suzanne. UPR-Mediated Membrane Biogenesis in B Cells. Biochemistry Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-494771
American Medical Association (AMA)
Brewer, Joseph W.& Jackowski, Suzanne. UPR-Mediated Membrane Biogenesis in B Cells. Biochemistry Research International. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-494771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494771