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Synaptic Conversion of Chloride-Dependent Synapses in Spinal Nociceptive Circuits : Roles in Neuropathic Pain
Joint Authors
Przebinda, Adam S.
Cooper, Mark S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Electrophysiological conversion of chloride-dependent synapses from inhibitory to excitatory function, as a result of aberrant neuronal chloride homeostasis, is a known mechanism for the genesis of neuropathic pain.
This paper examines theoretically how this type of synaptic conversion can disrupt circuit logic in spinal nociceptive circuits.
First, a mathematical scaling factor is developed to represent local aberration in chloride electrochemical driving potential.
Using this mathematical scaling factor, electrophysiological symbols are developed to represent the magnitude of synaptic conversion within nociceptive circuits.
When inserted into a nociceptive circuit diagram, these symbols assist in understanding the generation of neuropathic pain associated with the collapse of transmembrane chloride gradients.
A more generalized scaling factor is also derived to represent the interplay of chloride and bicarbonate driving potentials on the function of GABAergic and glycinergic synapses.
These mathematical and symbolic representations of synaptic conversion help illustrate the critical role that anion driving potentials play in the transduction of pain.
Using these representations, we discuss ramifications of glial-mediated synaptic conversion in the genesis, and treatment, of neuropathic pain.
American Psychological Association (APA)
Cooper, Mark S.& Przebinda, Adam S.. 2011. Synaptic Conversion of Chloride-Dependent Synapses in Spinal Nociceptive Circuits : Roles in Neuropathic Pain. Pain Research and Treatment،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-494792
Modern Language Association (MLA)
Cooper, Mark S.& Przebinda, Adam S.. Synaptic Conversion of Chloride-Dependent Synapses in Spinal Nociceptive Circuits : Roles in Neuropathic Pain. Pain Research and Treatment No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-494792
American Medical Association (AMA)
Cooper, Mark S.& Przebinda, Adam S.. Synaptic Conversion of Chloride-Dependent Synapses in Spinal Nociceptive Circuits : Roles in Neuropathic Pain. Pain Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-494792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494792