Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat
Joint Authors
Randall, David C.
Silcox, Dennis L.
Anigbogu, Chikodi N.
Brown, Laura C.
Karounos, Dennis G.
Williams, Daniel T.
Speakman, Richard O.
Brown, David R.
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n=8) were studied.
Age-matched diabetes-resistant rats (BBDR) served as controls.
BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0).
Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm.
These patterns changed during long-term diabetes.
The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ± 0.06; BBDR: 0.65 ± 0.03; P<.05).
These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease.
American Psychological Association (APA)
Anigbogu, Chikodi N.& Williams, Daniel T.& Brown, David R.& Silcox, Dennis L.& Speakman, Richard O.& Brown, Laura C.…[et al.]. 2011. Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-494796
Modern Language Association (MLA)
Anigbogu, Chikodi N.…[et al.]. Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat. International Journal of Hypertension No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-494796
American Medical Association (AMA)
Anigbogu, Chikodi N.& Williams, Daniel T.& Brown, David R.& Silcox, Dennis L.& Speakman, Richard O.& Brown, Laura C.…[et al.]. Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-494796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494796
