Synthesis and Antihypertensive Screening of New Derivatives of Quinazolines Linked with Isoxazole
Joint Authors
Shaharyar, Mohammad
Siddiqui, Anees A.
Parveen, Gazala
Rahman, Mujeeb Ur
Rathore, Ankita
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A series of 7-substituted-3-(4-(3-(4-substitutedphenyl)-4,5-dihydroisoxazol-5-yl)phenyl)-2-substituted quinazolin-4(3H)-one (1–30) have been synthesized by the cyclization of (E)-3-(4-(3-substitutedphenyl)acrylolyl)phenyl)-2-(substitutedphenyl)-7-substituted quinazolin-4-(3H)-one with hydroxylamine hydrochloride.
The synthesized compounds were examined for their in vivo antihypertensive activity using albino rats.
All the titled compounds exhibited good to moderate antihypertensive activity.
Compounds 7-Chloro-3-(4-(3-(4-chlorophenyl)-4,5- dihydroisoxazol-5-yl)phenyl)-2-p-tolylquinazolin-4(3H)-one (23) and 7-Chloro-3-(4-(3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)phenyl)-2-(4-methoxyphenyl)quinazolin-4(3H)-one (24) exhibited potent antihypertensive activity through their anticipated α1-adrenergic receptor blocking property similar to its clinically used analogue, prazosin, without affecting heart rate with prolonged duration of action when tested in adrenaline induced hypertension in anaesthetized rats.
American Psychological Association (APA)
Rahman, Mujeeb Ur& Rathore, Ankita& Siddiqui, Anees A.& Parveen, Gazala& Shaharyar, Mohammad. 2014. Synthesis and Antihypertensive Screening of New Derivatives of Quinazolines Linked with Isoxazole. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-494819
Modern Language Association (MLA)
Rahman, Mujeeb Ur…[et al.]. Synthesis and Antihypertensive Screening of New Derivatives of Quinazolines Linked with Isoxazole. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-494819
American Medical Association (AMA)
Rahman, Mujeeb Ur& Rathore, Ankita& Siddiqui, Anees A.& Parveen, Gazala& Shaharyar, Mohammad. Synthesis and Antihypertensive Screening of New Derivatives of Quinazolines Linked with Isoxazole. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-494819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494819