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Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549
Joint Authors
Lee, Mu-Jang
Liu, Jer-Yuh
Chen, Han-Min
Kao, Shao-Hsuan
Kuo, Cheng-Yi
Tsai, Pei-Lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ocimum gratissimum (OG) is widely used as a traditional herb for its antibacterial activity in Taiwan.
Recently, antitumor effect of OG on breast cancer cell is also reported; however, the effects of OG on human pulmonary adenocarcinoma cell A549 remain unclear.
Therefore, we aimed to investigate whether aqueous OG extract (OGE) affects viability of A549 cells and the signals induced by OGE in A549 cells.
Cell viability assays revealed that OGE significantly and dose-dependently decreased the viability of A549 cell but not that of BEAS-2B cell.
Morphological examination and DAPI staining indicated that OGE induced cell shrinkage and DNA condensation for A549 cells.
Further investigation showed that OGE enhanced activation of caspase-3, caspase-9 and caspase-8 and increased protein level of Apaf-1 and Bak, but diminished the level of Bcl-2.
Additionally, OGE inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) yet enhanced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 MAP kinase (p38).
In conclusion, our findings indicate that OGE suppressed the cell viability of A549 cells, which may result from the activation of apoptotic signaling and the inhibition of anti-apoptotic signaling, suggesting that OGE might be beneficial to lung carcinoma treatment.
American Psychological Association (APA)
Chen, Han-Min& Lee, Mu-Jang& Kuo, Cheng-Yi& Tsai, Pei-Lin& Liu, Jer-Yuh& Kao, Shao-Hsuan. 2010. Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-494822
Modern Language Association (MLA)
Chen, Han-Min…[et al.]. Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-494822
American Medical Association (AMA)
Chen, Han-Min& Lee, Mu-Jang& Kuo, Cheng-Yi& Tsai, Pei-Lin& Liu, Jer-Yuh& Kao, Shao-Hsuan. Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-494822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494822