Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma
Joint Authors
Li, John Zeng Hong
Wong, Thian-Sze
Gao, Wei
Ho, Wai Kuen
Chan, Jimmy Yu-Wai
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Laryngeal carcinoma is a common head and neck cancer with poor prognosis.
Patients with laryngeal carcinoma usually present late leading to the reduced treatment efficacy and high rate of recurrence.
Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment.
Epigenetics emerged as an important field in understanding the biology of the human malignancies.
Epigenetic alterations refer to the dysregulation of gene, which do not involve the alterations of the DNA sequence.
Major epigenetic changes including methylation imbalance, histone modification, and small RNA dysregulation could play a role in the development of human malignancies.
Global epigenetic change is now regarded as a molecular signature of cancer.
The characteristics and behavior of a cancer could be predicted based on the specific epigenetic pattern.
We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma.
Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use.
American Psychological Association (APA)
Wong, Thian-Sze& Gao, Wei& Li, John Zeng Hong& Chan, Jimmy Yu-Wai& Ho, Wai Kuen. 2012. Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma. Journal of Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494856
Modern Language Association (MLA)
Wong, Thian-Sze…[et al.]. Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma. Journal of Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-494856
American Medical Association (AMA)
Wong, Thian-Sze& Gao, Wei& Li, John Zeng Hong& Chan, Jimmy Yu-Wai& Ho, Wai Kuen. Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-494856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494856