Current Understanding on the Role of Standard and Immunoproteasomes in InflammatoryImmunological Pathways of Multiple Sclerosis

Joint Authors

Santoro, Aurelia
Mishto, Michele
Bellavista, Elena
Comi, Cristoforo
Luciani, Fabio
Galimberti, Daniela

Source

Autoimmune Diseases

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-01-02

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells.

As ubiquitin-proteasome system plays a critical role in the regulation of the immune system, it might also influence the development and progression of multiple sclerosis (MS).

Both ex vivo analyses and animal models suggest that activity and composition of ubiquitin-proteasome system are altered in MS.

Proteasome isoforms endowed of immunosubunits may affect the functionality of different cell types such as CD8+ and CD4+ T cells and B cells as well as neurons during MS development.

Furthermore, the study of proteasome-related biomarkers, such as proteasome antibodies and circulating proteasomes, may represent a field of interest in MS.

Proteasome inhibitors are already used as treatment for cancer and the recent development of inhibitors selective for immunoproteasome subunits may soon represent novel therapeutic approaches to the different forms of MS.

In this review we describe the current knowledge on the potential role of proteasomes in MS and discuss the pro et contra of possible therapies for MS targeting proteasome isoforms.

American Psychological Association (APA)

Bellavista, Elena& Santoro, Aurelia& Galimberti, Daniela& Comi, Cristoforo& Luciani, Fabio& Mishto, Michele. 2014. Current Understanding on the Role of Standard and Immunoproteasomes in InflammatoryImmunological Pathways of Multiple Sclerosis. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-494880

Modern Language Association (MLA)

Bellavista, Elena…[et al.]. Current Understanding on the Role of Standard and Immunoproteasomes in InflammatoryImmunological Pathways of Multiple Sclerosis. Autoimmune Diseases No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-494880

American Medical Association (AMA)

Bellavista, Elena& Santoro, Aurelia& Galimberti, Daniela& Comi, Cristoforo& Luciani, Fabio& Mishto, Michele. Current Understanding on the Role of Standard and Immunoproteasomes in InflammatoryImmunological Pathways of Multiple Sclerosis. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-494880

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-494880