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Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
Joint Authors
Panguluri, Siva K.
Tipparaju, Srinivas M.
Cooper, Nigel
Sneed, Kevin B.
Kuwabara, Nobuyuki
Lundy, Robert F.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Conditioned taste aversion (CTA) is an adaptive behavior that benefits survival of animals including humans and also serves as a powerful model to study the neural mechanisms of learning.
Memory formation is a necessary component of CTA learning and involves neural processing and regulation of gene expression in the amygdala.
Many studies have been focused on the identification of intracellular signaling cascades involved in CTA, but not late responsive genes underlying the long-lasting behavioral plasticity.
In this study, we explored in silico experiments to identify persistent changes in gene expression associated with CTA in rats.
We used oligonucleotide microarrays to identify 248 genes in the amygdala regulated by CTA.
Pathway Studio and IPA software analyses showed that the differentially expressed genes in the amygdala fall in diverse functional categories such as behavior, psychological disorders, nervous system development and function, and cell-to-cell signaling.
Conditioned taste aversion is a complex behavioral trait which involves association of visceral and taste inputs, consolidation of taste and visceral information, memory formation, retrieval of stored information, and extinction phase.
In silico analysis of differentially expressed genes is therefore necessary to manipulate specific phase/stage of CTA to understand the molecular insight.
American Psychological Association (APA)
Panguluri, Siva K.& Kuwabara, Nobuyuki& Cooper, Nigel& Tipparaju, Srinivas M.& Sneed, Kevin B.& Lundy, Robert F.. 2013. Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats. Neuroscience Journal،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-494886
Modern Language Association (MLA)
Panguluri, Siva K.…[et al.]. Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats. Neuroscience Journal No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-494886
American Medical Association (AMA)
Panguluri, Siva K.& Kuwabara, Nobuyuki& Cooper, Nigel& Tipparaju, Srinivas M.& Sneed, Kevin B.& Lundy, Robert F.. Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats. Neuroscience Journal. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-494886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494886