Cancer Malignancy Is Enhanced by Glyceraldehyde-Derived Advanced Glycation End-Products

Abstract EN

The receptor for advanced glycation end-products (RAGEs) is associated with the malignancy of cancer.

A recent study has suggested that glyceraldehyde-derived AGEs (Glycer-AGEs) enhanced the malignancy of melanoma cells, but glucose-derived AGEs did not.

However, the effects of Glycer-AGEs on other cancer cells remain poorly understood, and the molecular mechanisms behind the above-mentioned effect have not been clarified.

The present paper aimed to examine the effect of Glycer-AGEs on cultured lung cancer A549 cells.

RAGE was expressed in A549 cells.

Glycer-AGEs significantly attenuated cell proliferation.

Furthermore, Glycer-AGEs enhanced the migration capacity of the cells by activating Rac1 via ROS and also increased their invasion capacity.

We demonstrated that Glycer-AGEs enhanced the migration and invasion of A549 cells rather than their proliferation.

These results suggest that Glycer-AGEs play a critical role in the malignancy of cancer rather than its proliferation and are potential targets for therapeutic intervention.