Activation of Glycine and Extrasynaptic GABAA Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis

Joint Authors

Bhattarai, Janardhan Prasad
Park, Soo Joung
Nguyen, Thi Thanh Hoang
Han, Seong Kyu

Source

Neural Plasticity

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-11-28

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) has been known for the processing and transmission of orofacial nociceptive information.

Taurine, one of the most plentiful free amino-acids in humans, has proved to be involved in pain modulation.

In this study, using whole-cell patch clamp technique, we investigated the direct membrane effects of taurine and the action mechanism behind taurine-mediated responses on the SG neurons of the Vc.

Taurine showed non-desensitizing and repeatable membrane depolarizations and inward currents which remained in the presence of amino-acid receptors blocking cocktail (AARBC) with tetrodotoxin, indicating that taurine acts directly on the postsynaptic SG neurons.

Further, application of taurine at different doses (10 μM to 3 mM) showed a concentration dependent depolarizations and inward currents with the EC50 of 84.3 μM and 723 μM, respectively.

Taurine-mediated responses were partially blocked by picrotoxin (50 μM) and almost completely blocked by strychnine (2 μM), suggesting that taurine-mediated responses are via glycine receptor (GlyR) activation.

In addition, taurine (1 mM) activated extrasynaptic GABAA receptor (GABAAR)-mediated currents.

Taken together, our results indicate that taurine can be a target molecule for orofacial pain modulation through the activation of GlyRs and/or extrasynaptic GABAARs on the SG neurons.

American Psychological Association (APA)

Nguyen, Thi Thanh Hoang& Bhattarai, Janardhan Prasad& Park, Soo Joung& Han, Seong Kyu. 2013. Activation of Glycine and Extrasynaptic GABAA Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis. Neural Plasticity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-494945

Modern Language Association (MLA)

Nguyen, Thi Thanh Hoang…[et al.]. Activation of Glycine and Extrasynaptic GABAA Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis. Neural Plasticity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-494945

American Medical Association (AMA)

Nguyen, Thi Thanh Hoang& Bhattarai, Janardhan Prasad& Park, Soo Joung& Han, Seong Kyu. Activation of Glycine and Extrasynaptic GABAA Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-494945

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-494945