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Upregulation of Serum Vascular Endothelial Growth Factor in Patients with Salivary Gland Tumor
Joint Authors
Malekzadeh, Mahyar
Khademi, Bahar
Mardani, Maryam
Khademi, Bijan
Andisheh Tadbir, Azadeh
Source
Pathology Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Neoangiogenesis is essential for tumor development, invasion, and dissemination.
The most potent of the cytokines associated with angiogenesis is vascular endothelial growth factor (VEGF).
The aim of the present study was to determine VEGF serum level in patients with salivary gland tumor.
Using an ELISA kit, the circulating levels of VEGF in sera from 58 patients with salivary gland tumor and 30 healthy controls were assessed.
Mean VEGF levels in sera of patients with salivary gland tumors (574.9 ± 414.3) were significantly higher than those in controls (263.9 ± 310.0) (P=0.009).
Within the salivary gland tumor group, mean serum VEGF concentration in malignant tumors (n=27) was 727.3 ± 441.8 pg/mL, and that in benign tumors (n=31) was 442.2 ± 343.3 pg/mL.
Mean serum VEGF concentration was significantly higher in malignant tumors than in benign tumors (P=0.008) and was higher in benign tumors than in controls (P=0.03).
The data in the present study clearly show that VEGF level was consistently upregulated in benign and malignant tumors in comparison to healthy controls.
However, the role of VEGF as a prognostic factor in salivary gland tumor and its application in antiangiogenic therapy require further clinical research.
American Psychological Association (APA)
Andisheh Tadbir, Azadeh& Khademi, Bijan& Malekzadeh, Mahyar& Mardani, Maryam& Khademi, Bahar. 2013. Upregulation of Serum Vascular Endothelial Growth Factor in Patients with Salivary Gland Tumor. Pathology Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-494946
Modern Language Association (MLA)
Andisheh Tadbir, Azadeh…[et al.]. Upregulation of Serum Vascular Endothelial Growth Factor in Patients with Salivary Gland Tumor. Pathology Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-494946
American Medical Association (AMA)
Andisheh Tadbir, Azadeh& Khademi, Bijan& Malekzadeh, Mahyar& Mardani, Maryam& Khademi, Bahar. Upregulation of Serum Vascular Endothelial Growth Factor in Patients with Salivary Gland Tumor. Pathology Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-494946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494946