Three Types of Striational Antibodies in Myasthenia Gravis
Joint Authors
Suzuki, Norihiro
Nagane, Yuriko
Utsugisawa, Kimiaki
Suzuki, Shigeaki
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Myasthenia gravis (MG) is caused by antibodies that react mainly with the acetylcholine receptor on the postsynaptic site of the neuromuscular junction.
A wide range of clinical presentations and associated features allow MG to be classified into subtypes based on autoantibody status.
Striational antibodies, which react with epitopes on the muscle proteins titin, ryanodine receptor (RyR), and Kv1.4, are frequently found in MG patients with late-onset and thymoma.
Antititin and anti-RyR antibodies are determined by enzyme-linked immunosorbent assay or immunoblot.
More recently, a method for the detection of anti-Kv1.4 autoantibodies has become available, involving 12–15% of all MG patients.
The presence of striational antibodies is associated with more severe disease in all MG subgroups.
Anti-Kv1.4 antibody is a useful marker for the potential development of lethal autoimmune myocarditis and response to calcineurin inhibitors.
Detection of striational antibodies provides more specific and useful clinical information in MG patients.
American Psychological Association (APA)
Suzuki, Shigeaki& Utsugisawa, Kimiaki& Nagane, Yuriko& Suzuki, Norihiro. 2011. Three Types of Striational Antibodies in Myasthenia Gravis. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-494947
Modern Language Association (MLA)
Suzuki, Shigeaki…[et al.]. Three Types of Striational Antibodies in Myasthenia Gravis. Autoimmune Diseases No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-494947
American Medical Association (AMA)
Suzuki, Shigeaki& Utsugisawa, Kimiaki& Nagane, Yuriko& Suzuki, Norihiro. Three Types of Striational Antibodies in Myasthenia Gravis. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-494947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494947