Insulin Receptor Substrate-1 Expression Is Increased in Circulating Leukocytes of Patients with Acute Coronary Syndrome
Joint Authors
Bueno, Héctor
Andrés, Vicente
Jiménez-Navarro, Manuel F.
Alvarez-Sala, Luis
Rodríguez-Losada, Noela
González-Navarro, Herminia
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The mechanisms underlying the increased risk of cardiovascular disease associated with diabetes mellitus (DM) are not fully defined.
Insulin resistance in human metabolic syndrome patients is associated with decreased expression of the insulin receptor substrate-2- (Irs2-) AKT2 axis in mononuclear leukocytes (MLs).
Moreover, acute coronary syndrome (ACS) has been linked through genome-wide association studies to the 2q36-q37.3 locus, which contains the Irs1 gene.
Here, we investigated the expression of insulin-signaling pathway genes in MLs from patients with DM, ACS, and ACS plus DM.
Quantitative real-time PCR expression studies showed no differences in the mRNA levels of Irs2, Akt2, and Akt1 among all patients.
However, Irs1 mRNA expression was significantly increased in patients with ACS—diabetics and nondiabetics—compared with diabetic patients without ACS (P<.02 and P<.005, resp.).
The present study reveals for the first time an association between increased Irs1 mRNA levels in MLs of patients with ACS which is not related to DM.
American Psychological Association (APA)
Jiménez-Navarro, Manuel F.& Bueno, Héctor& Alvarez-Sala, Luis& Rodríguez-Losada, Noela& Andrés, Vicente& González-Navarro, Herminia. 2011. Insulin Receptor Substrate-1 Expression Is Increased in Circulating Leukocytes of Patients with Acute Coronary Syndrome. ISRN Cardiology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-494948
Modern Language Association (MLA)
Jiménez-Navarro, Manuel F.…[et al.]. Insulin Receptor Substrate-1 Expression Is Increased in Circulating Leukocytes of Patients with Acute Coronary Syndrome. ISRN Cardiology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-494948
American Medical Association (AMA)
Jiménez-Navarro, Manuel F.& Bueno, Héctor& Alvarez-Sala, Luis& Rodríguez-Losada, Noela& Andrés, Vicente& González-Navarro, Herminia. Insulin Receptor Substrate-1 Expression Is Increased in Circulating Leukocytes of Patients with Acute Coronary Syndrome. ISRN Cardiology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-494948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494948