High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue for Pediatric Brain Tumor Patients : A Single Institution Experience from UCLA
Joint Authors
Chang, Vivian Y.
Panosyan, Eduard H.
Bowles, La Vette
Laks, Dan R.
Ikeda, Alan K.
Moore, Theodore B.
Reeb, Charles L.
Lasky, Joseph L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Dose-dependent response makes certain pediatric brain tumors appropriate targets for high-dose chemotherapy with autologous hematopoietic stem-cell rescue (HDCT-AHSCR).
Methods.
The clinical outcomes and toxicities were analyzed retrospectively for 18 consecutive patients ≤19 y/o treated with HDCT-AHSCR at UCLA (1999–2009).
Results.
Patients' median age was 2.3 years.
Fourteen had primary and 4 recurrent tumors: 12 neural/embryonal (7 medulloblastomas, 4 primitive neuroectodermal tumors, and a pineoblastoma), 3 glial/mixed, and 3 germ cell tumors.
Eight patients had initial gross-total and seven subtotal resections.
HDCT mostly consisted of carboplatin and/or thiotepa ± etoposide (n=16).
Nine patients underwent a single AHSCR and nine ≥3 tandems.
Three-year progression-free and overall survival probabilities were 60.5% ± 16 and 69.3% ± 11.5.
Ten patients with pre-AHSCR complete remissions were alive/disease-free, whereas 5 of 8 with measurable disease were deceased (median followup: 2.3 yrs).
Nine of 13 survivors avoided radiation.
Single AHSCR regimens had greater toxicity than ≥3 AHSCR (P<.01).
Conclusion.
HDCT-AHSCR has a definitive, though limited role for selected pediatric brain tumors with poor prognosis and pretransplant complete/partial remissions.
American Psychological Association (APA)
Panosyan, Eduard H.& Ikeda, Alan K.& Chang, Vivian Y.& Laks, Dan R.& Reeb, Charles L.& Bowles, La Vette…[et al.]. 2011. High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue for Pediatric Brain Tumor Patients : A Single Institution Experience from UCLA. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-494962
Modern Language Association (MLA)
Panosyan, Eduard H.…[et al.]. High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue for Pediatric Brain Tumor Patients : A Single Institution Experience from UCLA. Journal of Transplantation No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-494962
American Medical Association (AMA)
Panosyan, Eduard H.& Ikeda, Alan K.& Chang, Vivian Y.& Laks, Dan R.& Reeb, Charles L.& Bowles, La Vette…[et al.]. High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue for Pediatric Brain Tumor Patients : A Single Institution Experience from UCLA. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-494962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494962