Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers
Joint Authors
Cuevas, Vivian Molina
Quintana, Daisy Carbajal
Guerra, Yohani Pérez
Yera, Ambar Oyarzábal
Despaigne, Sonia Jiménez
Ferreiro, Rosa Mas
Calzado, Yazmín Ravelo
Source
Advances in Pharmacological Sciences
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Effects of GSE and vitamins C and E on aspirin- and ethanol-induced gastric ulcer and associated increases of lipid peroxidation in rats were compared.
Two experiments were conducted.
Rats were randomized into eight groups: a negative control and seven groups that received aspirin or ethanol for ulcer induction: one positive control (vehicle) and six with VC, VE, or GSE (25 and 250 mg/kg).
Ulcer indexes and gastric levels of malondialdehyde (MDA) were quantified.
VC, VE, and GSE (25 and 250 mg/kg) decreased aspirin, and ethanol-induced ulcers and MDA values compared with positive control group.
The magnitude of aspirin ulcer reduction was comparable for all treatments, and MDA decrease with GSE was higher than with VC and tended to be greater, albeit none significantly, than with VE.
GSE was more effective than VC and VE for lowering the ethanol ulcers, while the decrease of MDA levels with GSE was greater than with VC, but comparable to that achieved with VE.
GSE protected against ethanol-induced gastric ulcers more effectively than VC or VE, while its protection against aspirin ulcers was comparable for all treatments.
GSE produced the greatest reductions of gastric MDA in both models.
American Psychological Association (APA)
Cuevas, Vivian Molina& Calzado, Yazmín Ravelo& Guerra, Yohani Pérez& Yera, Ambar Oyarzábal& Despaigne, Sonia Jiménez& Ferreiro, Rosa Mas…[et al.]. 2011. Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers. Advances in Pharmacological Sciences،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494964
Modern Language Association (MLA)
Cuevas, Vivian Molina…[et al.]. Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers. Advances in Pharmacological Sciences No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494964
American Medical Association (AMA)
Cuevas, Vivian Molina& Calzado, Yazmín Ravelo& Guerra, Yohani Pérez& Yera, Ambar Oyarzábal& Despaigne, Sonia Jiménez& Ferreiro, Rosa Mas…[et al.]. Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers. Advances in Pharmacological Sciences. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494964