Mitochondrial Hormesis in Pancreatic β Cells : Does Uncoupling Protein 2 Play a Role?
Joint Authors
Li, Ning
Maechler, Pierre
Stojanovski, Suzana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion.
Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function.
This is associated with elevated ROS production from overstimulated mitochondria.
Mitochondria are not only the major source of cellular ROS, they are also the primary target of ROS attacks.
The mitochondrial uncoupling protein UCP2, even though its uncoupling properties are debated, has been associated with protective functions against ROS toxicity.
Hormesis, an adaptive response to cellular stresses, might contribute to the protection against β-cell death, possibly limiting the development of type 2 diabetes.
Mitochondrial hormesis, or mitohormesis, is a defense mechanism observed in ROS-induced stress-responses by mitochondria.
In β cells, mitochondrial damages induced by sublethal exogenous H2O2 can induce secondary repair and defense mechanisms.
In this context, UCP2 is a marker of mitohormesis, being upregulated following stress conditions.
When overexpressed in nonstressed naïve cells, UCP2 confers resistance to oxidative stress.
Whether treatment with mitohormetic inducers is sufficient to restore or ameliorate secretory function of β cells remains to be determined.
American Psychological Association (APA)
Li, Ning& Stojanovski, Suzana& Maechler, Pierre. 2012. Mitochondrial Hormesis in Pancreatic β Cells : Does Uncoupling Protein 2 Play a Role?. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494977
Modern Language Association (MLA)
Li, Ning…[et al.]. Mitochondrial Hormesis in Pancreatic β Cells : Does Uncoupling Protein 2 Play a Role?. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-494977
American Medical Association (AMA)
Li, Ning& Stojanovski, Suzana& Maechler, Pierre. Mitochondrial Hormesis in Pancreatic β Cells : Does Uncoupling Protein 2 Play a Role?. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-494977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494977