The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population
Joint Authors
García, María de la Luz
Camarena, Angel
Teran, Luis Manuel
Pavón-Romero, Gandhi F.
Negrete-García, María Cristina
Galicia-Negrete, Gustavo
Falfán-Valencia, Ramcés
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aspirin exacerbated respiratory disease (AERD) is characterized by chronic hyperplastic rhinosinusitis, nasal polyposis, asthma, and aspirin sensitivity.
The mechanisms which produce these manifestations of intolerance are not fully defined, current research focuses on cyclooxygenase 1 (COX-1) inhibition, metabolism of arachidonic acid, and the COX pathway to the lipoxygenase (LO) route, inducing increased synthesis of leukotrienes (LT).
The biological plausibility of this model has led to the search for polymorphisms in genes responsible for proinflammatory cytokines synthesis, such as IL1B and IL8.
We performed a genetic association study between IL8-251 (rs4073) and IL1B-511 (rs16944) polymorphisms in AERD, aspirin-tolerant asthma (ATA), and healthy control subjects.
Using allelic discrimination by real-time PCR, we found statistically nonsignificant associations between AERD, ATA, and healthy control subjects for the GG and GA genotypes of IL1B (rs16944).
Interestingly, the AA genotype showed an increased frequency in the AERD patients versus the ATA group (GF = 0.19 versus 0.07, p=0.018, OR 2.98, and 95% CI 1.17–7.82).
This is the first observation that IL1B polymorphisms are involved in AERD.
Thus, future studies must investigate whether interleukin-1β is released in the airways of AERD patients and whether it relates to genetic polymorphisms in the IL1B gene.
American Psychological Association (APA)
Falfán-Valencia, Ramcés& Pavón-Romero, Gandhi F.& Camarena, Angel& García, María de la Luz& Galicia-Negrete, Gustavo& Negrete-García, María Cristina…[et al.]. 2011. The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population. Journal of Allergy،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495024
Modern Language Association (MLA)
Falfán-Valencia, Ramcés…[et al.]. The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population. Journal of Allergy No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-495024
American Medical Association (AMA)
Falfán-Valencia, Ramcés& Pavón-Romero, Gandhi F.& Camarena, Angel& García, María de la Luz& Galicia-Negrete, Gustavo& Negrete-García, María Cristina…[et al.]. The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population. Journal of Allergy. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-495024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495024