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Bis(ammonium) Zoledronate Dihydrate
Joint Authors
Sikorska, Małgorzata
Chojnacki, Jarosław
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Neutralization of 2-(1-imidazole)-1-hydroxyl-1,1′-ethylidenediphosphonic acid (zoledronic acid) by an excess of ammonia yielded bis(ammonium) zoledronate dihydrate, {C5H8N2O7P22-, 2(H4N+), 2(H2O)}.
The product is readily soluble in water and forms monocrystals for which the X-ray structural analysis was carried out.
The zoledronic anion is of double negative charge due to deprotonation of three P–OH groups and protonation of the nitrogen in the imidazole ring.
The structure is stabilized by extensive network of N–H⋯O and O–H⋯O hydrogen bonds expanding through the crystal in plane (002).
The imidazole ring is involved in π-π stacking interactions with its symmetry equivalents related by inversion centers at (1 0 0) and (1 1/2 0), with distances between centroids (Cg–Cg) of 3.819 (2) and 3.881 (2) Å, respectively.
American Psychological Association (APA)
Sikorska, Małgorzata& Chojnacki, Jarosław. 2013. Bis(ammonium) Zoledronate Dihydrate. Journal of Crystallography،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-495047
Modern Language Association (MLA)
Sikorska, Małgorzata& Chojnacki, Jarosław. Bis(ammonium) Zoledronate Dihydrate. Journal of Crystallography No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-495047
American Medical Association (AMA)
Sikorska, Małgorzata& Chojnacki, Jarosław. Bis(ammonium) Zoledronate Dihydrate. Journal of Crystallography. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-495047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495047