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Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems
Joint Authors
Becker, Susanne
Schweinhardt, Petra
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fibromyalgia is considered a stress-related disorder, and hypo- as well as hyperactive stress systems (sympathetic nervous system and hypothalamic-pituitary-adrenal axis) have been found.
Some observations raise doubts on the view that alterations in these stress systems are solely responsible for fibromyalgia symptoms.
Cumulative evidence points at dysfunctional transmitter systems that may underlie the major symptoms of the condition.
In addition, all transmitter systems found to be altered in fibromyalgia influence the body's stress systems.
Since both transmitter and stress systems change during chronic stress, it is conceivable that both systems change in parallel, interact, and contribute to the phenotype of fibromyalgia.
As we outline in this paper, subgroups of patients might exhibit varying degrees and types of transmitter dysfunction, explaining differences in symptomatoloy and contributing to the heterogeneity of fibromyalgia.
The finding that not all fibromyalgia patients respond to the same medications, targeting dysfunctional transmitter systems, further supports this hypothesis.
American Psychological Association (APA)
Becker, Susanne& Schweinhardt, Petra. 2011. Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495074
Modern Language Association (MLA)
Becker, Susanne& Schweinhardt, Petra. Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems. Pain Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-495074
American Medical Association (AMA)
Becker, Susanne& Schweinhardt, Petra. Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems. Pain Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-495074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495074