The Potential Role of Azadirachta indica Treatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats
Joint Authors
El-Deib, Kamal M.
Dkhil, Muhammad A.
al-Quraishy, Saleh
Aref, Ahmed M.
Abdel Moneim, Ahmed E.
Othman, Mohamed S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Azadirachta indica A.
Juss.
(neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India.
In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity.
Adult rats were randomly divided into four groups.
CDDP was given to rats by intraperitoneal injection, while MNLE was given by oral gavage for 5 days after the CDDP injection.
The injury and oxidative stress caused by CDDP on the liver and the effect of MNLE were evaluated by measuring (a) histological changes, (b) tissue biochemical oxidant and antioxidant parameters, and (c) investigating apoptosis markers immunohistochemically and by real time PCR.
After treatment with MNLE, the histological damage and apoptosis induction caused by cisplatin were improved.
Malondialdehyde and nitric oxide were significantly decreased; the antioxidant system, namely, glutathione content, glutathione-S-transferase, glutathione peroxidase, catalase, and superoxide dismutase activities were significantly elevated.
In conclusion, MNLE may have a potential role when combined with cisplatin in chemotherapy to alleviate cisplatin-induced damage and oxidative stress in liver.
American Psychological Association (APA)
Dkhil, Muhammad A.& al-Quraishy, Saleh& Aref, Ahmed M.& Othman, Mohamed S.& El-Deib, Kamal M.& Abdel Moneim, Ahmed E.. 2013. The Potential Role of Azadirachta indica Treatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-495083
Modern Language Association (MLA)
Dkhil, Muhammad A.…[et al.]. The Potential Role of Azadirachta indica Treatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-495083
American Medical Association (AMA)
Dkhil, Muhammad A.& al-Quraishy, Saleh& Aref, Ahmed M.& Othman, Mohamed S.& El-Deib, Kamal M.& Abdel Moneim, Ahmed E.. The Potential Role of Azadirachta indica Treatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-495083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495083