Oxidative Stress and Heart Failure in Altered Thyroid States
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Increased or reduced action of thyroid hormone on certain molecular pathways in the heart and vasculature causes relevant cardiovascular derangements.
It is well established that hyperthyroidism induces a hyperdynamic cardiovascular state, which is associated with a faster heart rate, enhanced left ventricular systolic and diastolic function whereas hypothyroidism is characterized by the opposite changes.
Hyperthyroidism and hypothyroidism represent opposite clinical conditions, albeit not mirror images.
Recent experimental and clinical studies have suggested the involvement of ROS tissue damage under altered thyroid status.
Altered-thyroid state-linked changes in heart modify their susceptibility to oxidants and the extent of the oxidative damage they suffer following oxidative challenge.
Chronic increase in the cellular levels of ROS can lead to a catastrophic cycle of DNA damage, mitochondrial dysfunction, further ROS generation and cellular injury.
Thus, these cellular events might play an important role in the development and progression of myocardial remodeling and heart failure in altered thyroid states (hypo- and hyper-thyroidism).
The present review aims at elucidating the various signaling pathways mediated via ROS and their modulation under altered thyroid state and the possibility of antioxidant therapy.
American Psychological Association (APA)
Mishra, Pallavi& Samanta, Luna. 2012. Oxidative Stress and Heart Failure in Altered Thyroid States. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-495088
Modern Language Association (MLA)
Mishra, Pallavi& Samanta, Luna. Oxidative Stress and Heart Failure in Altered Thyroid States. The Scientific World Journal No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-495088
American Medical Association (AMA)
Mishra, Pallavi& Samanta, Luna. Oxidative Stress and Heart Failure in Altered Thyroid States. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-495088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495088