Salivary Creatinine Estimation as an Alternative to Serum Creatinine in Chronic Kidney Disease Patients
Joint Authors
Venkatapathy, Ramesh
Prashad, Karthikshree V.
Pennagaram Dhanasekaran, Balamurali
Govindarajan, Vasupradha
Parameswaran, Sreejith
Oza, Nirima
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Context.
Sampling blood for serum analysis is an invasive procedure.
A noninvasive alternative would be beneficial to patients and health care professionals.
Aim.
To correlate serum and salivary creatinine levels and evaluate the role of saliva as a noninvasive alternative to serum for creatinine estimation in chronic kidney disease patients.
Study Design.
Case-control study.
Methods.
Blood and saliva samples were collected from 37 healthy individuals and 105 chronic kidney disease patients.
Serum and salivary creatinine levels were estimated using automatic analyser.
Statistical Analysis.
The serum and salivary creatinine levels between controls and cases were compared using t-test.
Correlation between serum and salivary creatinine was obtained in controls and cases using Pearson correlation coefficient.
Receiver operating characteristic analysis was done to assess the diagnostic performance of salivary creatinine.
Cut-off values were established for salivary creatinine.
Results.
Serum and salivary creatinine levels were significantly higher in CKD patients than controls.
The correlation was negative in controls and positive in cases.
Area under the curve for salivary creatinine was found to be 0.967.
A cut-off value of 0.2 mg/dL gave a sensitivity of 97.1% and specificity of 86.5%.
Conclusion.
Saliva can be used as a noninvasive alternative to serum for creatinine estimation.
American Psychological Association (APA)
Venkatapathy, Ramesh& Govindarajan, Vasupradha& Oza, Nirima& Parameswaran, Sreejith& Pennagaram Dhanasekaran, Balamurali& Prashad, Karthikshree V.. 2014. Salivary Creatinine Estimation as an Alternative to Serum Creatinine in Chronic Kidney Disease Patients. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-495169
Modern Language Association (MLA)
Venkatapathy, Ramesh…[et al.]. Salivary Creatinine Estimation as an Alternative to Serum Creatinine in Chronic Kidney Disease Patients. International Journal of Nephrology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-495169
American Medical Association (AMA)
Venkatapathy, Ramesh& Govindarajan, Vasupradha& Oza, Nirima& Parameswaran, Sreejith& Pennagaram Dhanasekaran, Balamurali& Prashad, Karthikshree V.. Salivary Creatinine Estimation as an Alternative to Serum Creatinine in Chronic Kidney Disease Patients. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-495169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495169