A Retrospective on Nuclear Receptor Regulation of Inflammation : Lessons from GR and PPARs
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Members of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation.
The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF-κB signaling pathways.
Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of inflammation.
This review examines the history and current advances in nuclear receptor regulation of inflammation by the crosstalk with AP-1 and NF-κB signaling, focusing on the roles of GR and PPARs.
A better understanding of the molecular mechanism by which nuclear receptors inhibit proinflammatory signaling pathways will enable novel therapies to treat chronic inflammation.
American Psychological Association (APA)
Li, Min-Dian& Yang, Xiaoyong. 2011. A Retrospective on Nuclear Receptor Regulation of Inflammation : Lessons from GR and PPARs. PPAR Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-495171
Modern Language Association (MLA)
Li, Min-Dian& Yang, Xiaoyong. A Retrospective on Nuclear Receptor Regulation of Inflammation : Lessons from GR and PPARs. PPAR Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-495171
American Medical Association (AMA)
Li, Min-Dian& Yang, Xiaoyong. A Retrospective on Nuclear Receptor Regulation of Inflammation : Lessons from GR and PPARs. PPAR Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-495171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495171