A Perfusion MRI Study of Emotional Valence and Arousal in Parkinson’s Disease
Joint Authors
Black, Kevin J.
Limsoontarakul, Sunsern
Campbell, Meghan C.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Background.
Brain regions subserving emotion have mostly been studied using functional magnetic resonance imaging (fMRI) during emotion provocation procedures in healthy participants.
Objective.
To identify neuroanatomical regions associated with spontaneous changes in emotional state over time.
Methods.
Self-rated emotional valence and arousal scores, and regional cerebral blood flow (rCBF) measured by perfusion MRI, were measured 4 or 8 times spanning at least 2 weeks in each of 21 subjects with Parkinson’s disease (PD).
A random-effects SPM analysis, corrected for multiple comparisons, identified significant clusters of contiguous voxels in which rCBF varied with valence or arousal.
Results.
Emotional valence correlated positively with rCBF in several brain regions, including medial globus pallidus, orbital prefrontal cortex (PFC), and white matter near putamen, thalamus, insula, and medial PFC.
Valence correlated negatively with rCBF in striatum, subgenual cingulate cortex, ventrolateral PFC, and precuneus—posterior cingulate cortex (PCC).
Arousal correlated positively with rCBF in clusters including claustrum-thalamus-ventral striatum and inferior parietal lobule and correlated negatively in clusters including posterior insula—mediodorsal thalamus and midbrain.
Conclusion.
This study demonstrates that the temporal stability of perfusion MRI allows within-subject investigations of spontaneous fluctuations in mental state, such as mood, over relatively long-time intervals.
American Psychological Association (APA)
Limsoontarakul, Sunsern& Campbell, Meghan C.& Black, Kevin J.. 2011. A Perfusion MRI Study of Emotional Valence and Arousal in Parkinson’s Disease. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-495183
Modern Language Association (MLA)
Limsoontarakul, Sunsern…[et al.]. A Perfusion MRI Study of Emotional Valence and Arousal in Parkinson’s Disease. Journal of Nanomaterials No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-495183
American Medical Association (AMA)
Limsoontarakul, Sunsern& Campbell, Meghan C.& Black, Kevin J.. A Perfusion MRI Study of Emotional Valence and Arousal in Parkinson’s Disease. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-495183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495183